GI Disease

From 2010 to 2014, researchers recruited 600 people aged 52 to 64 to participate in the case-control study. The frequency of colorectal advanced adenoma in 200 asymptomatic siblings of subjects with advanced adenomas was compared with 400 age-matched and sex-matched siblings of subjects with normal colonoscopies and no family history of colorectal cancer. Findings in both groups were validated by colonoscopy. Results show that subjects from the affected families had 6 times the chance of advanced adenoma compared with the subjects from the control group. They were also 3 times more likely to have adenoma of all kinds.

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